解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To investigate the pathophysiology of diabetic osteopenia, circulating levels and bone contents of bone gamma-carboxyglutamic acid-containing protein (BGP) were measured in streptozocin-induced diabetic rats . Plasma calcium and total protein were significantly decreased (P less than .01) in the diabetic group, and th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.6.702
更新日期:1988-06-01 00:00:00
abstract::Two sisters presented with severe insulin resistance and markedly decreased insulin binding to erythrocytes, cultured fibroblasts, and transformed lymphocytes. The dose-response curve of insulin-stimulated amino acid uptake in the fibroblasts was shifted to the right. The molecular weight of the insulin receptor on th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.5.653
更新日期:1988-05-01 00:00:00
abstract::Protein kinase C (PKC) has been suggested as a mediator of insulin's effect on glucose transport, and PKC-mediated modulation of tyrosine kinase activity in the insulin receptor has been implicated in regulating the insulin sensitivity of tissues. Because skeletal muscle is a major target of insulin action, we examine...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.5.499
更新日期:1988-05-01 00:00:00
abstract::Sorbitol accumulation, myo-inositol depletion, and reduced Na+-K+-ATPase activity have been identified in experimental diabetes in several tissues in which diabetic complications occur. However, a reduction in renal Na+-K+-ATPase activity has not been universally reported, prompting us to examine the influence of diab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.5.558
更新日期:1988-05-01 00:00:00
abstract::This study measured the accumulation of substance P-like immunoreactivity (SPLI) proximal and distal to 12-h constricting ligatures applied to rat sciatic nerves. There were three separate experiments, and the baseline for each consisted of control and age-matched rats with 3 wk of untreated streptozocin-induced diabe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.4.488
更新日期:1988-04-01 00:00:00
abstract::The Diabetes Control and Complications Trial (DCCT) is a multicenter randomized clinical trial studying the effect of intensive insulin therapy on the early vascular and neurological complications of insulin-dependent diabetes mellitus (IDDM). During the feasibility phase of the DCCT, baseline neurological histories, ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1988-04-01 00:00:00
abstract::We describe an automated method for the isolation of human pancreatic islets. The procedure meets the following requirements: 1) minimal traumatic action on the islets, 2) continuous digestion in which the islets that are progressively liberated can be saved from further enzymatic action, 3) minimal human intervention...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.4.413
更新日期:1988-04-01 00:00:00
abstract::Dispersed pancreatic endocrine cells (PECs) were recently shown to survive indefinitely in the brain of allogeneic diabetic rat recipients across the major histocompatibility barrier without immunosuppression. Purified PECs (2-3 X 10(6) cells) prepared from Wistar rat islets were transplanted in 10 different sites in ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.4.383
更新日期:1988-04-01 00:00:00
abstract::The plasma and tissue concentration of ascorbic acid (AA) is reduced in diabetes. This study was designed to investigate the mechanism and significance of this phenomenon. The low plasma AA concentration of diabetic rats can be normalized by dietary AA supplement (20-40 mg/day), a dosage approximately equal to the max...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.3.359
更新日期:1988-03-01 00:00:00
abstract::Six men with a low rate of insulin-stimulated, non-oxidative carbohydrate disposal (storage) and six with a high storage rate were recruited for study of the fate of insulin-stimulated glucose uptake. [3-3H]glucose was infused before and during a 4-h hyperinsulinemic euglycemic clamp procedure in a dosage regimen desi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.3.303
更新日期:1988-03-01 00:00:00
abstract::Polyalkylcyanoacrylate nanocapsules (mean size 220 nm), composed of spheric polymeric structures, have been used as a drug carrier for insulin. The rate of encapsulation of insulin is 54.9%, and we studied the therapeutic efficiency of the nanocapsules in diabetic and normal rats. When administered subcutaneously, ins...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.2.246
更新日期:1988-02-01 00:00:00
abstract::To determine the contribution of the rate of glucose recycling via the Cori cycle (glucose----3-carbon compounds----glucose) to the higher rate of endogenous glucose production (EGPR) in subjects with non-insulin-dependent diabetes mellitus (NIDDM), we studied eight obese, weight-stabilized diabetic Pima Indians befor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.37.2.154
更新日期:1988-02-01 00:00:00
abstract::A reduced thermic effect of glucose in non-insulin-dependent diabetes mellitus (NIDDM) has been previously reported. To investigate whether this defect is related to 1) a decreased rate of glucose storage, 2) a reduced energy cost of glucose storage, or 3) a defect in the sympathetically mediated component of thermoge...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.12.1441
更新日期:1987-12-01 00:00:00
abstract::Changes in tissue levels of sorbitol, myo-inositol, and Na+-K+-ATPase enzyme activity have been implicated in the development of diabetic complications in animal models of the disease and in humans. The ability of the aldose reductase inhibitor sorbinil to reverse the hyperglycemia-induced changes in these lenticular ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.12.1414
更新日期:1987-12-01 00:00:00
abstract::Embryo-culture techniques were used to study the effects of exposure to glucose-deficient culture media on rat embryos during organogenesis. Embryos and their extraembryonic membranes (explants) were cultured either in control media or in media with low or very low glucose concentrations. At the start of the culture t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.12.1372
更新日期:1987-12-01 00:00:00
abstract::The apolipoprotein E (apoE) phenotype and allele frequencies were examined in type II (non-insulin-dependent) diabetic patients with normolipidemia (n = 134) and hypercholesterolemia (type IIa hyperlipoproteinemia, n = 35; type IIb hyperlipoproteinemia, n = 42). The frequencies of apoE4-present phenotypes (apoE4/3, ap...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.11.1301
更新日期:1987-11-01 00:00:00
abstract::The effects of glucose and diabetes on the high-affinity lofentanil-displaceable opiate-receptor binding in mouse brain membranes were studied to determine if the attenuation of opiate actions by hyperglycemia previously observed in our laboratory was due to a modification of receptor affinity or number. With membrane...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.10.1173
更新日期:1987-10-01 00:00:00
abstract::To determine the role of prolactin in increasing junctional communication among islet beta-cells, we studied dye coupling in pancreatic islets exposed to elevated levels of prolactin in vivo and in vitro. Islets were isolated from rats immediately after lactation or from rats bearing mammosomatotropic tumors (MtTW15),...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.10.1098
更新日期:1987-10-01 00:00:00
abstract::This study addressed the controversial question of whether a negative-insulin-feedback loop exists in vivo. We utilized prehepatic insulin production, calculated by computerized deconvolution analysis of peripheral C-peptide concentration, as a measure of endogenous insulin secretion. Prehepatic insulin production was...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.36.8.959
更新日期:1987-08-01 00:00:00
abstract::Diabetes mellitus developing in BALB/c ByJ mice infected with the M variant of encephalomyocarditis (EMC) virus is dependent on thymic immune mechanisms. We treated mice with the anti-T-lymphocyte monoclonal anti-L3T4 and anti-Lyt2.2 antibodies before virus inoculation and monitored the infection and occurrence of dia...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.7.877
更新日期:1987-07-01 00:00:00
abstract::Na+-K+-ATPase or the Na+-K+ pump is essential for some specific properties of muscle and nerve tissue such as contractility and excitability. Previous studies have shown conflicting variations in Na+-K+-ATPase activity or Na+-K+ pump concentration of muscle cells in experimental diabetes. Our study demonstrates that e...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.7.842
更新日期:1987-07-01 00:00:00
abstract::To assess the extent to which the progression of diabetic retinopathy can be arrested by improved glycemic control, 35 normal dogs were randomly divided into a nondiabetic and three alloxan-induced diabetic groups prospectively identified according to glycemic control: poor control for 5 yr (PC), good control for 5 yr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.7.808
更新日期:1987-07-01 00:00:00
abstract::The plasma concentration of 1,5-anhydro-D-glucitol (AG) was measured in 135 newly diagnosed patients who were referred for oral glucose tolerance tests. AG concentrations in the nondiabetic patients indicated that the mean value of normal AG concentration was 21.8 micrograms/ml (SD = 5.9 micrograms/ml, range 9.6-38.8 ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.6.709
更新日期:1987-06-01 00:00:00
abstract::The inhibitory action of insulin and proinsulin on basal and glucagon-activated glycogenolysis was studied in cultured rat hepatocytes containing [14C]glycogen. Insulin or proinsulin given as sole hormones in the presence of 5 mM glucose decreased basal release of [14C]glucose from [14C]glycogen to 20%. Half-maximal e...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.5.551
更新日期:1987-05-01 00:00:00
abstract::Proliferation of vascular smooth muscle is thought to be involved in the major diabetic complication atherosclerosis. We have previously reported an increase of growth-promoting activity (GA) in platelets from insulin-dependent diabetics. In this study, GA was measured in the platelet extract (PE) from eight diabetic ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.5.667
更新日期:1987-05-01 00:00:00
abstract::The effect of 4 wk of streptozocin (STZ)-induced diabetes on the transmission time of the auditory-evoked brain stem response (ABR) was examined in conscious male Sprague-Dawley rats. Distal nerve transmission time of the auditory pathway (latency of peak II), which includes conduction along the 8th cranial nerve, inc...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.4.500
更新日期:1987-04-01 00:00:00
abstract::The effects of sulfated cholecystokinin (CCK-8S) and glucose on insulin secretion and polyphosphoinositide (PPI) metabolism were studied in isolated rat islets. Both agonists stimulate PPI hydrolysis, inositol phosphate accumulation, 3H efflux from [3H]inositol-prelabeled tissue, and 45Ca efflux from prelabeled cells....
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.4.426
更新日期:1987-04-01 00:00:00
abstract::The time course of islet cell antibodies (ICA) and serum C-peptides responses (CPRs) to oral glucose tolerance tests (OGTTs) were studied prospectively up to 60 (mean 35) mo in 32 ICA-positive subjects [28 with non-insulin-dependent diabetes (NIDDM) and 4 subjects with impaired glucose tolerance (IGT); mean age 45 yr]...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.4.510
更新日期:1987-04-01 00:00:00
abstract::Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.3.284
更新日期:1987-03-01 00:00:00
abstract::Spirometry was performed on 88 children with insulin-dependent diabetes mellitus (IDDM) and 216 healthy controls living in Sheffield. Children with IDDM had significantly lower percentage predicted forced vital capacity (FVC) than did control children or reference norms. There was no evidence that the reduced FVC was ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.3.324
更新日期:1987-03-01 00:00:00
abstract::Evidence in rodents suggests that islet pretreatment to reduce islet immunogenicity will also require some form of immunosuppression of the recipient for islet allograft acceptance in highly reactive donor-recipient pairs. We attempted to ascertain whether outbred dogs would also require treatment of both donor islets...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.3.269
更新日期:1987-03-01 00:00:00
abstract::To investigate the temporal relationship of diabetes-induced renal growth and its associated metabolic alterations to the early development of renal hyperfunction, parallel functional and metabolic studies were performed shortly after the onset of diabetes in rats. Hyperglycemia and hypoinsulinemia were evident 18 h a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.1.80
更新日期:1987-01-01 00:00:00
abstract::Cryopreservation of islets of Langerhans offers a number of important benefits for attempts to cure diabetes by transplantation. In the published literature, a variety of cooling rates, ranging from 0.25 to 75 degrees C/min, in conjunction with warming rates of 4-200 degrees C/min have been proposed to give optimal pr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.36.1.59
更新日期:1987-01-01 00:00:00
abstract::Patients with non-insulin-dependent diabetes mellitus (NIDDM) who have chronic hyperglycemia lose acute incremental insulin responses to glucose but are able to briskly respond to other beta-cell secretagogues. To investigate whether this is a defect specific for glucose or represents a more general phenomenon, we mea...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.12.1314
更新日期:1986-12-01 00:00:00
abstract::The pancreases of 14 children who died of type I diabetes were studied immunohistochemically for aberrant expression of HLA-DR antigens on islet endocrine cells. Two cases in which no residual insulin-secreting beta-cells were present had no evidence of HLA-DR expression on endocrine cells. Insulin-containing islets w...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.11.1215
更新日期:1986-11-01 00:00:00
abstract::Islets from male B10.BR mice (H-2k) were isolated by the collagenase technique, handpicked with a Pasteur pipette, and incubated (either intact or after dispersion with Dispase) for 0, 3, 5, 7, 10, or 14 days in tissue culture medium supplemented with either lymphokine supernatants or recombinant murine interferon-gam...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.10.1174
更新日期:1986-10-01 00:00:00
abstract::Effects of oral administration of DG-5128, a new oral hypoglycemic agent, on glycemic control after a mixed meal and an in vivo glucose disposal were measured in subjects with nonobese non-insulin-dependent diabetes mellitus (NIDDM). Oral administration of DG-5128 significantly (P less than .05) enhanced insulin secre...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.10.1085
更新日期:1986-10-01 00:00:00
abstract::Impairment of suppressor-cell activity may be important in the pathogenesis and maintenance of insulin-dependent diabetes mellitus (IDDM). In 23 recent-onset IDDM patients, lymphocyte sensitivity in vitro to theophylline was tested both in basal conditions and after improvement of metabolic control. This pharmacologic...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.9.1053
更新日期:1986-09-01 00:00:00
abstract::In evaluating therapeutic interventions aimed at preventing diabetic neuropathy, choosing a suitable measure of neural function is difficult, partly because the relation between most available objective measures and the development of symptomatic neuropathy (SN) is unclear. Using data from 67 diabetic patients, we dev...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.8.873
更新日期:1986-08-01 00:00:00
abstract::Groups of young adult rats with body weights of 125-135 g (group A) or 300-400 g (group B) were subjected to one bout of prolonged exercise to exhaustion on a treadmill and were studied 2 h postexercise. Liver glycogen levels were markedly depleted in the exercised rats. Adipocytes from group A exercised rats showed a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.35.7.785
更新日期:1986-07-01 00:00:00